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CEACAM3

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 3

Function

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Biological Process

Leukocyte migration Source: Reactome

Cellular Location

Membrane

Topology

Extracellular: 35-155
Helical: 156-176
Cytoplasmic: 177-252

PTM

Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

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Anti-CEACAM3 antibodies

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Mouse Anti-CEACAM3 Recombinant Antibody (CBYY-C0213) (CBMAB-C0615-YY)

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Target: CEACAM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C0213

Application*: F

Human CEACAM3 ELISA Kit (V2LY-0626-LY5556)

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Target: CEACAM3

Sensitivity: 0.048 ng/mL

Detection Range: 0.1-40 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human Recombinant CEACAM3 protein, His Tag (V2LY-0526-LY3080)

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Target: CEACAM3

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-155

Tag: His Tag

Mouse Anti-CEACAM3 Recombinant Antibody (CBT2228) (V2LY-0625-LY1530)

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Target: CEACAM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2228

Application*: WB, F

Mouse Anti-CEACAM3 Recombinant Antibody (CBT2690) (V2LY-0625-LY1529)

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Target: CEACAM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2690

Application*: WB, F

Mouse Anti-CEACAM3 Recombinant Antibody (CBYY-C1840) (CBMAB-C3278-YY)

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Target: CEACAM3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C1840

Application*: WB

Mouse Anti-CEACAM3 Recombinant Antibody (CBFYC-0069) (CBMAB-C0078-FY)

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Target: CEACAM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0069

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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