Mouse Anti-CEACAM3 Recombinant Antibody (CBYY-C1840) (CBMAB-C3278-YY)

Name: Mouse Anti-CEACAM3 Recombinant Antibody (CBYY-C1840)
SKU: CBMAB-C3278-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C1840

Application

Immunogen

Recombinant human CEACAM‑3/CD66d isoform 1 Lys35-Gly155.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 5% trehalose

Preservative

None

Concentration

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 3

Entrez Gene ID

1084

UniProt ID

P40198

Alternative Names

Centromere Protein A; Histone H3-Like Centromeric Protein A; Centromere-Specific Histone; Centromere Protein A, 17kDa; Centromere Autoantigen A; CENP-A; Centromere Protein A (17kD); CenH3;

Function

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Biological Process

Leukocyte migration Source: Reactome

Cellular Location

Membrane

Topology

Extracellular: 35-155
Helical: 156-176
Cytoplasmic: 177-252

PTM

Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

Klaile, E., Salcedo, J. P. P., Klassert, T. E., Besemer, M., Bothe, A. K., Durotin, A., ... & Slevogt, H. (2021). Antibody ligation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans. bioRxiv.

Bonsignore, P., Kuiper, J. W., Adrian, J., Goob, G., & Hauck, C. R. (2020). CEACAM3—A Prim (at) e Invention for Opsonin-Independent Phagocytosis of Bacteria. Frontiers in immunology, 10, 3160.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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