Mouse Anti-CEACAM3 Recombinant Antibody (CBFYC-0069) (CBMAB-C0078-FY)

Name: Mouse Anti-CEACAM3 Recombinant Antibody (CBFYC-0069)
SKU: CBMAB-C0078-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0069

Application

ELISA

Immunogen

Recombinant Human CEACAM3CD66d protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 3

Introduction

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.

Entrez Gene ID

1084

UniProt ID

P40198

Alternative Names

Carcinoembryonic Antigen Related Cell Adhesion Molecule 3; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3; Carcinoembryonic Antigen CGM1; CD66d Antigen; CD66D; CGM1

Function

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Biological Process

Leukocyte migration Source: Reactome

Cellular Location

Membrane

Topology

Extracellular: 35-155
Helical: 156-176
Cytoplasmic: 177-252

PTM

Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

Klaile, E., Salcedo, J. P. P., Klassert, T. E., Besemer, M., Bothe, A. K., Durotin, A., ... & Slevogt, H. (2021). Antibody ligation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans. bioRxiv.

Bonsignore, P., Kuiper, J. W., Adrian, J., Goob, G., & Hauck, C. R. (2020). CEACAM3—A Prim (at) e Invention for Opsonin-Independent Phagocytosis of Bacteria. Frontiers in immunology, 10, 3160.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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