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Mouse Anti-CEP63 Recombinant Antibody (CBXC-2136) (CBMAB-C5619-CQ)

This product is a mouse antibody that recognizes CEP63. The antibody CBXC-2136 can be used for immunoassay techniques such as: WB.
See all CEP63 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2136
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human CEP63(NP_001035859) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Centrosomal Protein 63
Introduction
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.
Entrez Gene ID
80254
UniProt ID
Q96MT8
Alternative Names
Centrosomal Protein 63; Centrosomal Protein 63kDa; Centrosomal Protein Of 63 KDa; Centrosome Protein CEP63; SCKL6; Cep63;
Function
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806).
Also recruits CDK1 to centrosomes (PubMed:21406398).
Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).
Biological Process
Cell division Source: UniProtKB-KW
Centriole replication Source: UniProtKB
Ciliary basal body-plasma membrane docking Source: Reactome
De novo centriole assembly involved in multi-ciliated epithelial cell differentiation Source: GO_Central
DNA damage checkpoint Source: UniProtKB
G2/M transition of mitotic cell cycle Source: Reactome
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Signal transduction in response to DNA damage Source: UniProtKB
Spindle assembly Source: UniProtKB
Cellular Location
Centrosome; Centriole; Centriolar satellite. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles.
Involvement in disease
Seckel syndrome 6 (SCKL6): A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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