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Mouse Anti-CHD3 Recombinant Antibody (CBT3628) (V2LY-0625-LY2358)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBT3628
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human CHD3 expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromodomain Helicase DNA Binding Protein 3
Entrez Gene ID
1107
UniProt ID
Q12873
Function
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (PubMed:9804427, PubMed:30397230).
Involved in transcriptional repressiobn as part of the NuRD complex (PubMed:27068747).
Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165).
Biological Process
ATP-dependent chromatin remodeling Source: UniProtKB
Centrosome cycle Source: UniProtKB
Chromatin assembly or disassembly Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Spindle organization Source: UniProtKB
Cellular Location
PML body; Nucleus; Centrosome. Associates with centrosomes in interphase and mitosis.
Involvement in disease
Snijders Blok-Campeau syndrome (SNIBCPS): An autosomal dominant neurodevelopmental disorder characterized by intellectual disability with a wide range of severity, developmental delay, and impaired speech and language skills. Speech-related problems include dysarthria, speech apraxia, oromotor problems, and stuttering. Additional clinical features are macrocephaly, characteristic facial features such as prominent forehead and hypertelorism, hypotonia, and joint laxity.
PTM
Sumoylation at Lys-1971 results in dissociation from chromatin and suppression of transcriptional repression.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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