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Rabbit Anti-CIAO1 Recombinant Antibody (D4E2U) (CBMAB-CP0312-LY)

The product is antibody recognizes CIAO1. The antibody D4E2U immunoassay techniques such as: WB.
See all CIAO1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D4E2U
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe292 of human CIAO1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CIAO1
Introduction
CIAO1 (Cytosolic Iron-Sulfur Assembly Component 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. An important paralog of this gene is WSB2.
Entrez Gene ID
Human9391
Mouse26371
Rat29231
UniProt ID
HumanO76071
MouseQ99KN2
RatQ5M7T1
Alternative Names
Cytosolic Iron-Sulfur Assembly Component 1; WD Repeat-Containing Protein 39; WD Repeat Domain 39; WDR39; Cytosolic Iron-Sulfur Protein Assembly 1 Homolog (S. Cerevisiae); Probable Cytosolic Iron-Sulfur Protein Assembly Protein CIAO1;
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004).

As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004).

Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563).

As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).
Biological Process
Chromosome segregation Source: UniProtKB-KW
Iron-sulfur cluster assembly Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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