CIAO1

CIAO1 (Cytosolic Iron-Sulfur Assembly Component 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. An important paralog of this gene is WSB2.

CIAO1

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004).

As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004).

Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563).

As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).

Chromosome segregation Source: UniProtKB-KW
Iron-sulfur cluster assembly Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc

Cytoplasm