CIAO1

CIAO1 (Cytosolic Iron-Sulfur Assembly Component 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. An important paralog of this gene is WSB2.
Full Name
CIAO1
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004).

As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004).

Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563).

As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).
Biological Process
Chromosome segregation Source: UniProtKB-KW
Iron-sulfur cluster assembly Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Cytoplasm
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Anti-CIAO1 antibodies

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Mouse Anti-CIAO1 Recombinant Antibody (CBXC-2998) (CBMAB-C0314-CQ)

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Target: CIAO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-2998
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CIAO1 Recombinant Antibody (6C9) (CBMAB-C0001-WJ)

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Target: CIAO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6C9
Application*: E, WB
Datasheet SDS

Mouse Anti-CIAO1 Recombinant Antibody (0230) (CBMAB-0230-YC)

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Target: CIAO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 0230
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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