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Mouse Anti-CIAO1 Recombinant Antibody (CBXC-2998) (CBMAB-C0314-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-2998
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-339 of Ciao 1 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CIAO1
Introduction
CIAO1 (Cytosolic Iron-Sulfur Assembly Component 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. An important paralog of this gene is WSB2.
Entrez Gene ID
9391
UniProt ID
O76071
Alternative Names
Cytosolic Iron-Sulfur Assembly Component 1; WD Repeat-Containing Protein 39; WD Repeat Domain 39; WDR39; Cytosolic Iron-Sulfur Protein Assembly 1 Homolog (S. Cerevisiae); Probable Cytosolic Iron-Sulfur Protein Assembly Protein CIAO1;
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004).

As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004).

Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563).

As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).
Biological Process
Chromosome segregation Source: UniProtKB-KW
Iron-sulfur cluster assembly Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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