Sign in or Register   Sign in or Register
  |  

Mouse Anti-CLEC1B Recombinant Antibody (AYP1) (CBMAB-AP1539LY)


See all CLEC1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
AYP1
Antibody Isotype
IgG1
Application
FA, FC, IF, IP

Basic Information

Immunogen
A recombinant extracellular fragment of human CLEC-2 (aa 68-229), which is the extracellular domain of the protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-type lectin domain family 1, member B
Entrez Gene ID
51266
UniProt ID
Q9P126
Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137).

After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).

(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).

(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Defense response Source: ProtInc
Platelet activation Source: Reactome
Signal transduction Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-229
PTM
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CLEC1B Recombinant Antibody (AYP1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare