Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-CLIP1 Recombinant Antibody (EG729) (V2LY-1206-LY242)


See all CLIP1 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG729
Antibody Isotype
IgG
Application
WB, IHC

Basic Information

Immunogen
A synthesized peptide derived from human CLIP170.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol, 0.4-0.5mg/ml BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CAP-Gly Domain Containing Linker Protein 1
Entrez Gene ID
Human6249
Mouse56430
Rat65201
UniProt ID
HumanP30622
MouseQ922J3
RatQ9JK25
Function
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Biological Process
Cytoplasmic microtubule organization Source: GO_Central
Microtubule bundle formation Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic spindle organization Source: Reactome
Positive regulation of microtubule polymerization Source: UniProtKB
Cellular Location
Cytoskeleton; Cytoplasm; Cytoplasmic vesicle membrane. Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698).
PTM
Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (By similarity). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (PubMed:12231510).
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CLIP1 Recombinant Antibody (EG729)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry