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Mouse Anti-CNTN1 Recombinant Antibody (CBLNC-148) (CBMAB-1407-CN)

This product is a mouse antibody that recognizes CNTN1 of human. The antibody CBLNC-148 can be used for immunoassay techniques such as: WB, IHC, ICC, IP.
See all CNTN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLNC-148
Antibody Isotype
IgG
Application
WB, IHC, ICC, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Contactin 1
Introduction
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus.
Entrez Gene ID
1272
UniProt ID
Q12860
Alternative Names
F3; GP135; MYPCN
Function
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Biological Process
Cell adhesion Source: ProtInc
Cerebellum development Source: Ensembl
Neuron projection development Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Myopathy, congenital, Compton-North (MYPCN):
A lethal, autosomal recessive, congenital myopathy characterized by fetal akinesia, neonatal hypotonia, severe muscle weakness, loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma and disruption of sarcomeres with disorganization of the Z band.

Pascual-Goñi, E., Fehmi, J., Lleixà, C., Martín-Aguilar, L., Devaux, J., Höftberger, R., ... & Querol, L. (2021). Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy. Brain, 144(4), 1183-1196.

Wieske, L., Martín-Aguilar, L., Fehmi, J., Lleixà, C., Koel-Simmelink, M. J., Chatterjee, M., ... & Eftimov, F. (2021). Serum contactin-1 in CIDP: A cross-sectional study. Neurology-Neuroimmunology Neuroinflammation, 8(5).

Zhang, M., Yu, Q., Tang, W., Wu, Y., Lv, J., Sun, L., ... & Xia, Z. (2021). Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell–dominant T-cell responses in asthma. Journal of Allergy and Clinical Immunology, 148(6), 1545-1558.

Cortese, A., Lombardi, R., Briani, C., Callegari, I., Benedetti, L., Manganelli, F., ... & Franciotta, D. (2020). Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: clinical relevance of IgG isotype. Neurology-Neuroimmunology Neuroinflammation, 7(1).

Gu, Y., Li, T., Kapoor, A., Major, P., & Tang, D. (2020). Contactin 1: An important and emerging oncogenic protein promoting cancer progression and metastasis. Genes, 11(8), 874.

Fehmi, J., Davies, A. J., Antonelou, M., Teunissen, C. E., Keddie, S., Pikkupeura, S., ... & Rinaldi, S. (2020). Contactin-1 antibodies link autoimmune neuropathies to nephrotic syndrome.

Veny, M., Grases, D., Kucharova, K., Lin, W. W., Nguyen, J., Huang, S., ... & Šedý, J. R. (2020). Contactin-1 is required for peripheral innervation and immune homeostasis within the intestinal mucosa. Frontiers in Immunology, 11, 1268.

Chen, N., He, S., Geng, J., Song, Z. J., Han, P. H., Qin, J., ... & Dang, C. X. (2018). Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells. BMC cell biology, 19(1), 1-8.

Chen, Y. A., Lu, I., & Tsai, J. W. (2018). Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating RhoA activity. Frontiers in molecular neuroscience, 422.

Ocklenburg, S., Gerding, W. M., Arning, L., Genç, E., Epplen, J. T., Güntürkün, O., & Beste, C. (2017). Myelin genes and the corpus callosum: proteolipid protein 1 (PLP1) and contactin 1 (CNTN1) gene variation modulates interhemispheric integration. Molecular Neurobiology, 54(10), 7908-7916.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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