Mouse Anti-COASY Recombinant Antibody (CBFYC-2024) (V2LY-1206-LY562)

Name: Mouse Anti-COASY Recombinant Antibody (CBFYC-2024)
SKU: V2LY-1206-LY562
Rating: 5 (1 reviews)

See all COASY antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2024

Application

WB, IP, ELISA

Immunogen

Recombinant COASY of human.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Coenzyme A Synthase

Entrez Gene ID

80347

UniProt ID

Q13057

Function

Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.

Biological Process

Coenzyme A biosynthetic process Source: UniProtKB

Cellular Location

Mitochondrion matrix; Cytoplasm. The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate.

Involvement in disease

Neurodegeneration with brain iron accumulation 6 (NBIA6):
A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive motor and cognitive dysfunction beginning in childhood or young adulthood. Patients show extrapyramidal motor signs, such as spasticity, dystonia, and parkinsonism.
Pontocerebellar hypoplasia 12 (PCH12):
A form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum, evident upon brain imaging. PCH12 is an autosomal recessive form characterized by onset in utero and death in infancy. Brain imaging shows microcephaly, cerebellar hypoplasia, micrognathia, and multiple contractures.

Ferrandon, S., DeVecchio, J., Duraes, L., Chouhan, H., Karagkounis, G., Davenport, J., ... & Kalady, M. F. (2020). CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer. Cancer research, 80(2), 334-346.

Chambers, E., Hermann, E., Davis, D., Montgomery, M., Lucas, E., & Chowanadisai, W. (2020). Brain MRI Phenotypes Associated with Polymorphisms at or near the MAPT (Microtubule Associated Protein Tau) and COASY (Coenzyme A Synthase) Genes. Current Developments in Nutrition, 4(Supplement_2), 1246-1246.

van Dijk, T., Ferdinandusse, S., Ruiter, J. P., Alders, M., Mathijssen, I. B., Parboosingh, J. S., ... & Baas, F. (2018). Biallelic loss of function variants in COASY cause prenatal onset pontocerebellar hypoplasia, microcephaly, and arthrogryposis. European Journal of Human Genetics, 26(12), 1752-1758.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-COASY Recombinant Antibody (CBFYC-2024)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

COASY Matched Antibody Pair (284) (CAT#: APMAB-284LY)

COASY Matched Antibody Pair (285) (CAT#: APMAB-285LY)

Related Products

COASY Matched Antibody Pair (285) (CAT#: APMAB-285LY)

Rabbit Anti-COASY Recombinant Antibody (CBFYC-2026) (CAT#: V2LY-1206-LY564)

Mouse Anti-COASY Recombinant Antibody (CBFYC-2025) (CAT#: V2LY-1206-LY563)

COASY Matched Antibody Pair (284) (CAT#: APMAB-284LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry