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Mouse Anti-COL9A1 Recombinant Antibody (CBFYC-2084) (V2LY-1206-LY706)


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Published Data
V2LY-1206-LY706-1
Mouse Anti-COL9A1 Recombinant Antibody (CBFYC-2084) (V2LY-1206-LY706) in IF
Immunofluorescence staining of collagen and aggrecan in primary ACCs and SBOLs. Magnification: 200×. ...View More
Li, M., Zhang, L., Li, J., & Zhu, Q. (2022). Direct Reprogramming of Mouse Subchondral Bone Osteoblasts into Chondrocyte-like Cells. Biomedicines, 10(10), 2582.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-2084
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 532-612 mapping within an internal region of Collagen α1 Type IX of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type IX Alpha 1 Chain
Entrez Gene ID
Human1297
Mouse12839
Rat305104
UniProt ID
HumanP20849
MouseQ05722
RatP20850
Function
Structural component of hyaline cartilage and vitreous of the eye.
Biological Process
Animal organ morphogenesis Source: ProtInc
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: GO_Central
Cellular Location
Extracellular matrix
Involvement in disease
Multiple epiphyseal dysplasia 6 (EDM6):
A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal.
Stickler syndrome 4 (STL4):
An autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable.
PTM
Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
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For research use only. Not intended for any clinical use.

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