Mouse Anti-COMMD8 Recombinant Antibody (CBLC170-LY) (V2LY-1206-LY728)

Name: Mouse Anti-COMMD8 Recombinant Antibody (CBLC170-LY)
SKU: V2LY-1206-LY728
Rating: 5 (1 reviews)

See all COMMD8 antibodies

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Summary

Host Animal

Mouse

Specificity

Mouse, Rat

Clone

CBLC170-LY

Antibody Isotype

IgG2a, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Amino acids 33-56 within an internal region of COMMD8 of mouse.

Host Species

Mouse

Specificity

Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

COMM Domain Containing 8

Entrez Gene ID

Mouse	27784
Rat	289603

UniProt ID

Mouse	Q9CZG3
Rat	B0K015

Function

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237).

May down-regulate activation of NF-kappa-B (PubMed:15799966).

Cellular Location

Cytoplasm; Nucleus

More Infomation

References

Kempiński, K., Romantowski, J., Maciejewska, A., Pawłowski, R., Chełmińska, M., Jassem, E., & Niedoszytko, M. (2020). COMMD8 changes expression during initial phase of wasp venom immunotherapy. The Journal of Gene Medicine, 22(11), e3243.

Zhang, R., Niu, Z., Pei, H., & Peng, Z. (2020). Long noncoding RNA LINC00657 induced by SP1 contributes to the non‐small cell lung cancer progression through targeting miR‐26b‐5p/COMMD8 axis. Journal of cellular physiology, 235(4), 3340-3349.

Wang, S., Wang, T., Liu, D., & Kong, H. (2020). LncRNA MALAT1 aggravates the progression of non-small cell lung cancer by stimulating the expression of COMMD8 via targeting miR-613. Cancer Management and Research, 12, 10735.

Nakai, A., Fujimoto, J., Miyata, H., Stumm, R., Narazaki, M., Schulz, S., ... & Suzuki, K. (2019). The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. Journal of Experimental Medicine, 216(7), 1630-1647.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-COMMD8 Recombinant Antibody (CBFYC-2090)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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