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Mouse Anti-CRELD2 Recombinant Antibody (C4712) (V2LY-1206-LY1136)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Pig
Clone
C4712
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 141-173 within an internal region of human CRELD2.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cysteine Rich With EGF Like Domains 2
Entrez Gene ID
Human79174
Mouse76737
Rat362978
UniProt ID
HumanQ6UXH1
MouseQ9CYA0
RatQ4G063
Function
Protein disulfide isomerase (By similarity).

Might play a role in the unfolded protein response (By similarity).

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698).
Cellular Location
Endoplasmic reticulum
More Infomation

Lasić, V., Kosović, I., Jurić, M., Racetin, A., Čurčić, J., Šolić, I., ... & Vukojević, K. (2021). GREB1L, CRELD2 and ITGA10 expression in the human developmental and postnatal kidneys: an immunohistochemical study. Acta Histochemica, 123(2), 151679.

Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., ... & Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.

Dennis, E. P., Edwards, S. M., Jackson, R. M., Hartley, C. L., Tsompani, D., Capulli, M., ... & Briggs, M. D. (2020). CRELD2 is a novel LRP1 chaperone that regulates noncanonical WNT signaling in skeletal development. Journal of Bone and Mineral Research, 35(8), 1452-1469.

Chen, M. F., Chang, C. H., Yang, L. Y., Hsieh, P. H., Shih, H. N., Ueng, S. W. N., & Chang, Y. (2019). Synovial fluid interleukin-16, interleukin-18, and CRELD2 as novel biomarkers of prosthetic joint infections. Bone & Joint Research, 8(4), 179-188.

Yu, N., Wang, X., Bao, H., & Liu, Z. (2019). Identification and functional study of three nAChR regulators, ubiquilin‐1, PICK 1, and CRELD 2, in Locusta migratoria manilensis dorsal unpaired median neurons. Journal of Neurochemistry, 149(3), 331-345.

Oh-Hashi, K., Fujimura, K., Norisada, J., & Hirata, Y. (2018). Expression analysis and functional characterization of the mouse cysteine-rich with EGF-like domains 2. Scientific reports, 8(1), 1-11.

Kim, Y., Park, S. J., Manson, S. R., Molina, C. A., Kidd, K., Thiessen-Philbrook, H., ... & Chen, Y. M. (2017). Elevated urinary CRELD2 is associated with endoplasmic reticulum stress–mediated kidney disease. JCI insight, 2(23).

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For research use only. Not intended for any clinical use.

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