Mouse Anti-CRELD2 Recombinant Antibody (C4712) (V2LY-1206-LY1136)

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Basic Information

Host Animal
Mouse
Clone
C4712
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 141-173 within an internal region of human CRELD2.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Cysteine Rich With EGF Like Domains 2
Entrez Gene ID
Human79174
Mouse76737
Rat362978
UniProt ID
HumanQ6UXH1
MouseQ9CYA0
RatQ4G063
Function
Protein disulfide isomerase (By similarity).

Might play a role in the unfolded protein response (By similarity).

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698).
Cellular Location
Endoplasmic reticulum

Lasić, V., Kosović, I., Jurić, M., Racetin, A., Čurčić, J., Šolić, I., ... & Vukojević, K. (2021). GREB1L, CRELD2 and ITGA10 expression in the human developmental and postnatal kidneys: an immunohistochemical study. Acta Histochemica, 123(2), 151679.

Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., ... & Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.

Dennis, E. P., Edwards, S. M., Jackson, R. M., Hartley, C. L., Tsompani, D., Capulli, M., ... & Briggs, M. D. (2020). CRELD2 is a novel LRP1 chaperone that regulates noncanonical WNT signaling in skeletal development. Journal of Bone and Mineral Research, 35(8), 1452-1469.

Chen, M. F., Chang, C. H., Yang, L. Y., Hsieh, P. H., Shih, H. N., Ueng, S. W. N., & Chang, Y. (2019). Synovial fluid interleukin-16, interleukin-18, and CRELD2 as novel biomarkers of prosthetic joint infections. Bone & Joint Research, 8(4), 179-188.

Yu, N., Wang, X., Bao, H., & Liu, Z. (2019). Identification and functional study of three nAChR regulators, ubiquilin‐1, PICK 1, and CRELD 2, in Locusta migratoria manilensis dorsal unpaired median neurons. Journal of Neurochemistry, 149(3), 331-345.

Oh-Hashi, K., Fujimura, K., Norisada, J., & Hirata, Y. (2018). Expression analysis and functional characterization of the mouse cysteine-rich with EGF-like domains 2. Scientific reports, 8(1), 1-11.

Kim, Y., Park, S. J., Manson, S. R., Molina, C. A., Kidd, K., Thiessen-Philbrook, H., ... & Chen, Y. M. (2017). Elevated urinary CRELD2 is associated with endoplasmic reticulum stress–mediated kidney disease. JCI insight, 2(23).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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