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Mouse Anti-CRHBP Recombinant Antibody (3D9) (V2LY-1206-LY1150)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D9
Antibody Isotype
IgG2b, κ
Application
ELISA, IP

Basic Information

Immunogen
Full-length recombinant CRHBP.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Corticotropin Releasing Hormone Binding Protein
Entrez Gene ID
1393
UniProt ID
P24387
Function
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Biological Process
Behavioral response to ethanol Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to cAMP Source: UniProtKB
Cellular response to cocaine Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to estradiol stimulus Source: UniProtKB
Cellular response to estrogen stimulus Source: UniProtKB
Cellular response to gonadotropin-releasing hormone Source: UniProtKB
Cellular response to potassium ion Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Female pregnancy Source: UniProtKB
Hormone-mediated signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Learning or memory Source: UniProtKB
Negative regulation of corticotropin-releasing hormone receptor activity Source: UniProtKB
Negative regulation of corticotropin secretion Source: UniProtKB
Regulated exocytosis Source: UniProtKB
Regulation of cellular response to stress Source: UniProtKB
Regulation of corticotropin secretion Source: UniProtKB
Regulation of NMDA receptor activity Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, dopaminergic Source: UniProtKB
Cellular Location
Secreted
More Infomation

Adachi, N., Suzuki, S., Matsuoka, H., Fushimi, S., Ono, J., Ohta, K. I., ... & Koshimizu, H. (2018). Corticotropin‐releasing hormone‐binding protein is up‐regulated by brain‐derived neurotrophic factor and is secreted in an activity‐dependent manner in rat cerebral cortical neurons. Journal of neurochemistry, 146(1), 99-110.

Fabbri, C., Lewis, C. M., Perlis, R. H., & Uher, R. (2018). No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. American Journal of Psychiatry, 175(6), 575-576.

Xia, H. B., Wang, H. J., Fu, L. Q., Wang, S. B., Li, L., Ru, G. Q., ... & Huang, D. S. (2018). Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 16(3), 3681-3689.

Haass-Koffler, C. L. (2018). The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system?. Alcohol, 72, 3-8.

O’Connell, C. P., Goldstein-Piekarski, A. N., Nemeroff, C. B., Schatzberg, A. F., Debattista, C., Carrillo-Roa, T., ... & Williams, L. M. (2018). Antidepressant outcomes predicted by genetic variation in corticotropin-releasing hormone binding protein. American Journal of Psychiatry, 175(3), 251-261.

Kalin, N. H. (2018). Corticotropin-Releasing Hormone Binding Protein: Stress, Psychopathology, and Antidepressant Treatment Response. American Journal of Psychiatry, 175(3), 204-206.

Ketchesin, K. D., Stinnett, G. S., & Seasholtz, A. F. (2017). Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans. Stress, 20(5), 449-464.

Su, F., Xia, Y., Huang, M., Zhang, L., & Chen, L. (2017). Up-regulation of corticotropin releasing hormone is associated with the downregulation of corticotropin releasing hormone binding protein and up-regulation of IL-33 and IL-8 expression in psoriasis. Tropical Journal of Pharmaceutical Research, 16(11), 2595-2600.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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