Mouse Anti-CRYBB2 Recombinant Antibody (CBFYC-2254) (V2LY-1206-LY1318)

Name: Mouse Anti-CRYBB2 Recombinant Antibody (CBFYC-2254)
SKU: V2LY-1206-LY1318
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat, Dog, Cattle, Pig

Clone

CBFYC-2254

Antibody Isotype

IgG1, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Amino acids 29-67 within an internal region of human βB2-crystallin.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog, Cattle, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Crystallin Beta B2

Entrez Gene ID

Mouse	12961
Rat	25422

UniProt ID

Mouse	P62696
Rat	P62697

Function

Crystallins are the dominant structural components of the vertebrate eye lens.

Biological Process

Lens development in camera-type eye Source: GO_Central
Response to stimulus Source: UniProtKB-KW
Visual perception Source: GO_Central

Involvement in disease

Cataract 3, multiple types (CTRCT3):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT3 includes congenital cerulean and sutural cataract with punctate and cerulean opacities, among others. Cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract. Sutural cataract with punctate and cerulean opacities is characterized by white opacification around the anterior and posterior Y sutures, and grayish and bluish, spindle shaped, oval punctate and cerulean opacities of various sizes arranged in lamellar form. The spots are more concentrated towards the peripheral layers and do not delineate the embryonal or fetal nucleus. Phenotypic variation with respect to the size and density of the sutural opacities as well as the number and position of punctate and cerulean spots is observed among affected subjects.

More Infomation

References

Xu, L. J., Lv, Z. G., Liu, Y., Zhang, X. X., Cui, Y. X., Li, X. C., ... & He, J. (2021). A novel CRYBB2 mutation causes autosomal dominant cataract: A report from a Chinese family. European Journal of Ophthalmology, 31(5), NP57-NP64.

Chen, D., & Zhu, S. (2021). Whole‑exome sequencing identification of a recurrent CRYBB2 variant in a four‑generation Chinese family with congenital nuclear cataracts. Experimental and Therapeutic Medicine, 22(6), 1-13.

Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Maul, S., Straube, A., ... & Rujescu, D. (2020). Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function. Translational Psychiatry, 10(1), 1-12.

Sun, M., Ahmad, N., Zhang, R., & Graw, J. (2018). Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis. Biochemical and biophysical research communications, 503(1), 123-130.

Chen, P., Chen, H., Pan, X. J., Tang, S. Z., Xia, Y. J., & Zhang, H. (2018). Novel mutations in CRYBB1/CRYBB2 identified by targeted exome sequencing in Chinese families with congenital cataract. International Journal of Ophthalmology, 11(10), 1577.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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