Mouse Anti-CYB5R1 Recombinant Antibody (4B7) (V2LY-0125-LY835)

Name: Mouse Anti-CYB5R1 Recombinant Antibody (4B7)
SKU: V2LY-0125-LY835
Rating: 5 (1 reviews)

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Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

4B7

Antibody Isotype

IgG1

Application

IF, IHC, WB

Basic Information

Immunogen

Full length human recombinant protein of human CYB5R1 produced in HEK293T cell.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:150
WB	1:2,000
IF(ICC)	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA, Glycerol & PBS

Preservative

Sodium Azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cytochrome B5 Reductase 1

Entrez Gene ID

51706

UniProt ID

Q9UHQ9

Function

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

Biological Process

Bicarbonate transport Source: Reactome
Platelet degranulation Source: Reactome
Sterol biosynthetic process Source: UniProtKB-KW

Cellular Location

Membrane

Topology

Helical: 8-28

More Infomation

References

Yan, B., Ai, Y., Sun, Q., Ma, Y., Cao, Y., Wang, J., ... & Wang, X. (2021). Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Molecular cell, 81(2), 355-369.

Ai, Y., Yan, B., & Wang, X. (2021). The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis. Molecular & Cellular Oncology, 8(2), 1881393.

Yan, B., Ai, Y., Zhang, Z., & Wang, X. (2021). Assessing POR and CYB5R1 oxidoreductase-mediated oxidative rupture of PUFA in liposomes. STAR protocols, 2(1), 100360.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CYB5R1 Recombinant Antibody (2D10)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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