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Mouse Anti-DCTN2 Recombinant Antibody (2G7) (CBMAB-D0411-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynactin Subunit 2 (DCTN2). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all DCTN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G7
Antibody Isotype
IgG, λ
Application
ELISA, IF, WB

Basic Information

Immunogen
DCTN2 (AAH00718, 302 a.a. ~ 401 a.a) partial recombinant protein with GST tag. The immunogen sequence: DADTQSKVHQ LYETIQRWSP IASTLPELVQ RLVTIKQLHE QAMQFGQLLT HLDTTQQMIA NSLKDNTTLL TQVQTTMREN LATVEGNFAS IDERMKKLGK
Specificity
Human
Antibody Isotype
IgG, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 302-401

Target

Full Name
Dynactin Subunit 2
Introduction
DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Entrez Gene ID
10540
UniProt ID
Q13561
Alternative Names
Dynactin Subunit 2; 50 KDa Dynein-Associated Polypeptide; Dynactin Complex 50 KDa Subunit; Dynactin 2 (P50); P50 Dynamitin; DCTN50;
Function
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Ciliary basal body-plasma membrane docking Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Melanosome transport Source: Ensembl
Mitotic metaphase plate congression Source: UniProtKB
Mitotic spindle organization Source: UniProtKB
Protein localization to centrosome Source: SYSCILIA_CCNET
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Cellular Location
Centrosome; Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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