DCTN2 Matched Antibody Pair (325) (APMAB-325LY)

This antibody pair set can be used for detecting and quantifying protein level of human DCTN2.
See all DCTN2 antibodies

Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-DCTN2 polyclonal antibody, 100 ug

Detection Antibody

Anti-DCTN2 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Alternative Names

Dynactin Subunit 2; 50 KDa Dynein-Associated Polypeptide; Dynactin Complex 50 KDa Subunit; Dynactin 2 (P50); P50 Dynamitin; DCTN50;

Entrez Gene ID

10540

UniProt ID

Q13561

References

Li, Y. F., Shi, L. J., Wang, P., Wang, J. W., Shi, G. Y., & Lee, S. C. (2021). Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells. Oncology reports, 46(1), 1-11.

Lee, Y. D., Kim, B., Jung, S., Kim, H., Kim, M. K., Kwon, J. O., ... & Kim, H. H. (2020). The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway. Experimental & molecular medicine, 52(3), 514-528.

D’Aurora, M., Budani, M. C., Franchi, S., Sarra, A., Stuppia, L., Tiboni, G. M., & Gatta, V. (2019). Dynactin pathway-related gene expression is altered by aging, but not by vitrification. Reproductive Toxicology, 88, 48-55.

Wang, S., Wang, Q., Zhang, X., Liao, X., Wang, G., Yu, L., ... & Yuan, W. (2018). Distinct prognostic value of dynactin subunit 4 (DCTN4) and diagnostic value of DCTN1, DCTN2, and DCTN4 in colon adenocarcinoma. Cancer Management and Research, 10, 5807.

Shen, C., Honda, H., Suzuki, S. O., Maeda, N., Shijo, M., Hamasaki, H., ... & Iwaki, T. (2018). Dynactin is involved in Lewy body pathology. Neuropathology, 38(6), 583-590.

Wang, Q., Wang, X., Liang, Q., Wang, S., Liao, X., Li, D., & Pan, F. (2018). Prognostic value of dynactin mRNA expression in cutaneous melanoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 24, 3752.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-DCTN2 Recombinant Antibody (2G7)

Mouse Anti-DCTN2 Recombinant Antibody (25/Dynactin p50)

Mouse Anti-DCTN2 Recombinant Antibody (MANDYS8)

Mouse Anti-DCTN2 Recombinant Antibody (770)

Mouse Anti-DCTN2 Recombinant Antibody (5E4C2F3)

Mouse Anti-DCTN2 Recombinant Antibody (CF139)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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