DCTN2

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Full Name

Dynactin Subunit 2

Function

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Ciliary basal body-plasma membrane docking Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Melanosome transport Source: Ensembl
Mitotic metaphase plate congression Source: UniProtKB
Mitotic spindle organization Source: UniProtKB
Protein localization to centrosome Source: SYSCILIA_CCNET
Regulation of G2/M transition of mitotic cell cycle Source: Reactome

Cellular Location

Centrosome; Membrane