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Rabbit Anti-DDX4 Recombinant Antibody (CBYY-1020) (V2LY-0425-LY70)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYY-1020
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Recombinant protein within the C-terminus region of human DDX4.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DEAD-Box Helicase 4
Entrez Gene ID
Human54514
Mouse13206
UniProt ID
HumanQ9NQI0
MouseQ61496
Alternative Names
DEAD-Bovinex Helicase 4; DEAD/H (Asp-Glu-Ala-Asp/His) Bovinex Polypeptide 4; DEAD (Asp-Glu-Ala-Asp) Bovinex Polypeptide 4; DEAD Bovinex Protein 4; Vasa Homolog; VASA; Probable ATP-Dependent RNA Helicase DDX4; EC 3.6.4.13; EC 3.6.1;
Function
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600).

Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity).

Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity).

Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity).

Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity).
Biological Process
Cell differentiation Source: GO_Central
DNA methylation involved in gamete generation Source: UniProtKB
Flagellated sperm motility Source: UniProtKB
Gamete generation Source: GO_Central
Gene silencing by RNA Source: UniProtKB-KW
Male meiosis I Source: UniProtKB
Male meiotic nuclear division Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of transposition Source: UniProtKB
PiRNA biosynthetic process Source: UniProtKB
PiRNA metabolic process Source: UniProtKB
Spermatogenesis Source: UniProtKB
Cellular Location
Cytoplasm; Perinuclear region. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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