Mouse Anti-DSG4 Recombinant Antibody (6E7) (CBMAB-D1792-YC)

Name: Mouse Anti-DSG4 Recombinant Antibody (6E7)
SKU: CBMAB-D1792-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6E7

Application

ELISA, WB

Immunogen

DSG4 (NP_817123, 531 a.a. ~ 630 a.a) partial recombinant protein with GST tag. The immunogen sequence: EPPGIADMWD VRSTNATSAI LTAKQVLSPG FYEIPILVKD SYNRACELAQ MVQLYACDCD DNHMCLDSGA AGIYTEDITG DTYGPVTEDQ AGVSNVGLGP

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 531-630

More Infomation

Target

Full Name

desmoglein 4

Introduction

DSG4 belongs to the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth.

Entrez Gene ID

147409

UniProt ID

Q86SJ6

Alternative Names

Desmoglein 4; Cadherin Family Member 13; CDHF13; Desmoglein-4; CDGF13; HYPT6; LAH;

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).

Biological Process

Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Cellular Location

Cell membrane; Desmosome

Involvement in disease

Hypotrichosis 6 (HYPT6):
A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. HYPT6 inheritance is autosomal recessive.
Autoantibodies against DSG4 are found in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.

Topology

Extracellular: 50-631
Helical: 632-652
Cytoplasmic: 653-1040

Moreno-Sosa, T., Sánchez, M. B., Pietrobon, E. O., Fernandez-Muñoz, J. M., Zoppino, F. C. M., Neira, F. J., ... & Mackern-Oberti, J. P. (2021). Desmoglein-4 deficiency exacerbates psoriasiform dermatitis in rats while psoriasis patients displayed a decreased gene expression of DSG4. Frontiers in immunology, 12, 708.

Gouin, O., Barbieux, C., Leturcq, F., Des Claustres, M. B., Petrova, E., & Hovnanian, A. (2020). Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation, and IL-36 signature. Journal of Investigative Dermatology, 140(6), 1184-1194.

Cohen-Barak, E., Danial-Farran, N., Hammad, H., Aleme, O., Krauz, J., Gavish, E., ... & Shalev, S. (2018). Desmoglein 4 mutation underlies autosomal recessive keratosis pilaris atrophicans. Acta Dermato-Venereologica, 98(7-8), 809-810.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DSG4 Recombinant Antibody (6E7) (CAT#: V2LY-0425-LY1001)

Related Products

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Mouse Anti-DSG4 Recombinant Antibody (CBYCD-426) (CAT#: V2LY-0425-LY1000)

Mouse Anti-DSG4 Recombinant Antibody (6E7) (CAT#: V2LY-0425-LY1001)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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