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Mouse Anti-DSG4 Recombinant Antibody (6E7) (CBMAB-D1792-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Desmoglein 4 (DSG4). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DSG4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E7
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
DSG4 (NP_817123, 531 a.a. ~ 630 a.a) partial recombinant protein with GST tag. The immunogen sequence: EPPGIADMWD VRSTNATSAI LTAKQVLSPG FYEIPILVKD SYNRACELAQ MVQLYACDCD DNHMCLDSGA AGIYTEDITG DTYGPVTEDQ AGVSNVGLGP
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 531-630

Target

Full Name
desmoglein 4
Introduction
DSG4 belongs to the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth.
Entrez Gene ID
UniProt ID
Alternative Names
Desmoglein 4; Cadherin Family Member 13; CDHF13; Desmoglein-4; CDGF13; HYPT6; LAH;
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
Biological Process
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Hypotrichosis 6 (HYPT6):
A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. HYPT6 inheritance is autosomal recessive.
Autoantibodies against DSG4 are found in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
Topology
Extracellular: 50-631
Helical: 632-652
Cytoplasmic: 653-1040
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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