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Rabbit Anti-DUSP4 Recombinant Antibody (EG1003) (CBMAB-EN1186-LY)

The product is antibody recognizes DUS4. The antibody EG1003 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000.
See all DUSP4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1003
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human DUS4.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dual Specificity Phosphatase 4
Entrez Gene ID
Human1846
Mouse319520
Rat60587
UniProt ID
HumanQ13115
MouseQ8BFV3
RatQ62767
Research Area
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Biological Process
Dephosphorylation Source: UniProtKB
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein.

Su, H., Jiang, M., Senevirathne, C., Aluri, S., Zhang, T., Guo, H., ... & Zhao, X. (2021). Methylation of dual-specificity phosphatase 4 controls cell differentiation. Cell Reports, 36(4), 109421.

Gupta, A., Towers, C., Willenbrock, F., Brant, R., Hodgson, D. R., Sharpe, A., ... & Macaulay, V. M. (2020). Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma. British journal of cancer, 122(4), 506-516.

Ratsada, P., Hijiya, N., Hidano, S., Tsukamoto, Y., Nakada, C., Uchida, T., ... & Moriyama, M. (2020). DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells. Biochemical and Biophysical Research Communications, 528(3), 586-593.

Haddock, A. N., Labuzan, S. A., Haynes, A. E., Hayes, C. S., Kakareka, K. M., & Waddell, D. S. (2019). Dual-specificity phosphatase 4 is upregulated during skeletal muscle atrophy and modulates extracellular signal-regulated kinase activity. American Journal of Physiology-Cell Physiology, 316(4), C567-C581.

Prihantono, P., Usman, A. N., Binekada, C., Hatta, M., & Islam, A. A. (2019). Patterns of dual-specific phosphatase 4 mRNA expression before and after neoadjuvant chemotherapy in breast cancer. Asian Pacific Journal of Cancer Prevention: APJCP, 20(4), 1051.

Hofmann, S. R., Mäbert, K., Kapplusch, F., Russ, S., Northey, S., Beresford, M. W., ... & Hedrich, C. M. (2019). cAMP response element modulator α induces dual specificity protein phosphatase 4 to promote effector T cells in juvenile-onset lupus. The Journal of Immunology, 203(11), 2807-2816.

Ichimanda, M., Hijiya, N., Tsukamoto, Y., Uchida, T., Nakada, C., Akagi, T., ... & Moriyama, M. (2018). Downregulation of dual‐specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas. Cancer Science, 109(1), 250-258.

Kobayashi, Y., Ito, K., Kanda, A., Tomoda, K., Mercado, N., & Barnes, P. J. (2017). Impaired dual-specificity protein phosphatase DUSP4 reduces corticosteroid sensitivity. Molecular Pharmacology, 91(5), 475-481.

Dougherty, J. A., Kilbane Myers, J., Khan, M., Angelos, M. G., & Chen, C. A. (2017). Dual-specificity phosphatase 4 overexpression in cells prevents hypoxia/reoxygenation-induced apoptosis via the upregulation of eNOS. Frontiers in Cardiovascular Medicine, 4, 22.

Kang, X., Li, M., Zhu, H., Lu, X., Miao, J., Du, S., ... & Guan, W. (2017). DUSP4 promotes doxorubicin resistance in gastric cancer through epithelial-mesenchymal transition. Oncotarget, 8(55), 94028.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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