DUSP4

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
Full Name
Dual Specificity Phosphatase 4
Research Area
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Biological Process
Dephosphorylation Source: UniProtKB
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein.
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Anti-DUSP4 antibodies

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Mouse Anti-DUSP4 Recombinant Antibody (CBFYM-1076) (CBMAB-M1229-FY)

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Target: DUSP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Horse, Catttle, Pig
Clone: CBFYM-1076
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DUSP4 Recombinant Antibody (48) (CBMAB-M1231-FY)

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Target: DUSP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 48
Application*: WB
Datasheet SDS

Rabbit Anti-DUSP4 Recombinant Antibody (D1904) (CBMAB-D1904-YC)

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Target: DUSP4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D1904
Application*: WB
Datasheet SDS

Mouse Anti-DUSP4 Recombinant Antibody (8C121) (CBMAB-D1903-YC)

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Target: DUSP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 8C121
Application*: WB
Datasheet SDS

Mouse Anti-DUSP4 Recombinant Antibody (3D6-G6) (V2LY-0425-LY1078)

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Target: DUSP4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3D6-G6
Application*: E, WB
Datasheet SDS

Mouse Anti-DUSP4 Recombinant Antibody (1D12) (V2LY-0425-LY1075)

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Target: DUSP4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 1D12
Application*: E, WB, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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