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Rabbit Anti-EDEM2 Recombinant Antibody (CBWJC-3602) (CBMAB-C4843WJ)

This product is a Rabbit antibody that recognizes EDEM2. This antibody CBWJC-3602 can be used for immunoassay techniques such as: WB.
See all EDEM2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJC-3602
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.076 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ER Degradation Enhancing Alpha-Mannosidase Like Protein 2
Introduction
EDEM2 (ER Degradation Enhancing Alpha-Mannosidase Like Protein 2) is a Protein Coding gene. Among its related pathways are Calnexin/calreticulin cycle and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is EDEM3.
Entrez Gene ID
55741
UniProt ID
Q9BV94
Alternative Names
C20orf31; C20orf49; bA4204.1
Research Area
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655).

May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655).

Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).
Biological Process
Carbohydrate metabolic process Source: InterPro
Mannose trimming involved in glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Positive regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Response to unfolded protein Source: UniProtKB-KW
Trimming of first mannose on A branch Source: Reactome
Trimming of second mannose on A branch Source: Reactome
Trimming of terminal mannose on B branch Source: ParkinsonsUK-UCL
Trimming of terminal mannose on C branch Source: Reactome
Ubiquitin-dependent glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Viral protein processing Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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