EDEM2

EDEM2 (ER Degradation Enhancing Alpha-Mannosidase Like Protein 2) is a Protein Coding gene. Among its related pathways are Calnexin/calreticulin cycle and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is EDEM3.

Full Name

ER Degradation Enhancing Alpha-Mannosidase Like Protein 2

Research Area

Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655).

May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655).

Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).

Biological Process

Carbohydrate metabolic process Source: InterPro
Mannose trimming involved in glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Positive regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Response to unfolded protein Source: UniProtKB-KW
Trimming of first mannose on A branch Source: Reactome
Trimming of second mannose on A branch Source: Reactome
Trimming of terminal mannose on B branch Source: ParkinsonsUK-UCL
Trimming of terminal mannose on C branch Source: Reactome
Ubiquitin-dependent glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Viral protein processing Source: Reactome

Cellular Location

Endoplasmic reticulum lumen

PTM

N-glycosylated.