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Mouse Anti-EDEM2 (AA 479-579) Recombinant Antibody (CBFYE-0436) (CBMAB-E0757-FY)

This product is mouse antibody that recognizes EDEM2. The antibody CBFYE-0436 can be used for immunoassay techniques such as: ELISA, IHC, IP, WB.
See all EDEM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0436
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa479-579 from human C20orf31 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 479-579

Target

Full Name
ER Degradation Enhancing Alpha-Mannosidase Like Protein 2
Introduction
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins.
Entrez Gene ID
UniProt ID
Alternative Names
C20orf31; C20orf49; bA4204.1
Research Area
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655).

May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655).

Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).
Biological Process
Carbohydrate metabolic process Source: InterPro
Mannose trimming involved in glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Positive regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Response to unfolded protein Source: UniProtKB-KW
Trimming of first mannose on A branch Source: Reactome
Trimming of second mannose on A branch Source: Reactome
Trimming of terminal mannose on B branch Source: ParkinsonsUK-UCL
Trimming of terminal mannose on C branch Source: Reactome
Ubiquitin-dependent glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Viral protein processing Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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