Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-EFNA1 Recombinant Antibody (1177) (V2LY-0425-LY1499)


See all EFNA1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
1177
Antibody Isotype
IgG
Application
WB, ELISA

Basic Information

Immunogen
Recombinant full length protein of human EFNA1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:20,000
WB1:100-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & PBS
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ephrin A1
Entrez Gene ID
1942
UniProt ID
P20827
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Biological Process
Angiogenesis Source: UniProtKB-KW
Aortic valve morphogenesis Source: BHF-UCL
Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell migration Source: UniProtKB
Endocardial cushion to mesenchymal transition involved in heart valve formation Source: BHF-UCL
Ephrin receptor signaling pathway Source: UniProtKB
Mitral valve morphogenesis Source: BHF-UCL
Negative regulation of dendritic spine morphogenesis Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
Negative regulation of MAPK cascade Source: Ensembl
Negative regulation of proteolysis involved in cellular protein catabolic process Source: ARUK-UCL
Negative regulation of thymocyte apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Notochord formation Source: Ensembl
Positive regulation of amyloid-beta formation Source: ARUK-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Protein stabilization Source: ARUK-UCL
Regulation of angiogenesis Source: Ensembl
Regulation of axonogenesis Source: Ensembl
Regulation of blood vessel endothelial cell migration Source: Ensembl
Regulation of cell adhesion mediated by integrin Source: UniProtKB
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Substrate adhesion-dependent cell spreading Source: UniProtKB
Cellular Location
Cell membrane
Ephrin-A1, secreted form: Secreted
PTM
Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EFNA1 Recombinant Antibody (1177)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry