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Mouse Anti-ELK4 Recombinant Antibody (CBXS-2285) (CBMAB-S5047-CQ)

This product is a mouse antibody that recognizes ELK4. The antibody CBXS-2285 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ELK4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2285
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELK4, ETS-domain protein (SRF accessory protein 1)
Introduction
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.
Entrez Gene ID
2005
UniProt ID
P28324
Alternative Names
ELK4, ETS Transcription Factor; ELK4, ETS-Domain Protein (SRF Accessory Protein 1); Serum Response Factor Accessory Protein 1; SRF Accessory Protein 1; SAP-1; SAP1; ETS Domain-Containing Protein Elk-4;
Research Area
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
Biological Process
Cell differentiation Source: GO_Central
Histone H3 deacetylation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Yang, W., Gao, K., Qian, Y., Huang, Y., Xiang, Q., Chen, C., ... & Zhai, R. (2022). A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes. Journal of hematology & oncology, 15(1), 1-20.

Long, R., Liu, Z., Li, J., Zhang, Y., & Yu, H. (2021). HCG11 up-regulation induced by ELK4 suppressed proliferation in vestibular schwannoma by targeting miR-620/ELK4. Cancer Cell International, 21(1), 1-10.

Zheng, L., Xu, H., Di, Y., Chen, L., Liu, J., Kang, L., & Gao, L. (2021). ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis. Journal of translational medicine, 19(1), 1-13.

Mao, X., Ji, T., Liu, A., & Weng, Y. (2021). ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis. Cell death & disease, 12(11), 1-11.

Mao, C., Dong, W., Lu, J., Zhang, Z., Wu, H., Ghavamian, A., ... & Ding, S. (2021). βKlotho Inhibits Cell Proliferation by Downregulating ELK4 and Predicts Favorable Prognosis in Prostate Cancer. Cancer Management and Research, 13, 6377.

Zhu, Z., Song, J., Guo, Y., Huang, Z., Chen, X., Dang, X., ... & Cui, L. (2020). LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer. Oncogene, 39(24), 4666-4680.

Liu, Q., Zhu, L., Liu, X., Zheng, J., Liu, Y., Ruan, X., ... & Xue, Y. (2020). TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer’s microenvironment. RNA biology, 17(9), 1293-1308.

Olafsen, C. E., Cooper, A., Britton, J., Pira, C. U., & Oberg, K. C. (2020). An ELK4 Binding Site is Critical for Activity of the LHX2-Associated Sub-AER Regulatory Module 1 (LASARM1). The FASEB Journal, 34(S1), 1-1.

Maurice, D., Costello, P., Sargent, M., & Treisman, R. (2018). ERK signaling controls innate-like CD8+ T cell differentiation via the ELK4 (SAP-1) and ELK1 transcription factors. The Journal of Immunology, 201(6), 1681-1691.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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