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Rabbit Anti-ENPP7 Recombinant Antibody (CBFYE-0899) (CBMAB-E1366-FY)

This product is rabbit antibody that recognizes ENPP7. The antibody CBFYE-0899 can be used for immunoassay techniques such as: ELISA.
See all ENPP7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYE-0899
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human ENPP7 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ectonucleotide Pyrophosphatase/Phosphodiesterase 7
Introduction
The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity.
Entrez Gene ID
UniProt ID
Alternative Names
Ectonucleotide Pyrophosphatase/Phosphodiesterase 7; Alkaline Sphingomyelin Phosphodiesterase; Intestinal Alkaline Sphingomyelinase; Alkaline Sphingomyelinase; ALK-SMase; E-NPP 7
Research Area
Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:16255717, PubMed:28292932).

Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation (PubMed:16255717, PubMed:12885774).

Does not have nucleotide pyrophosphatase activity (PubMed:12885774).

May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity).
Biological Process
Fatty acid homeostasis Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Lipid digestion Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of DNA replication Source: UniProtKB
Positive regulation of ceramide biosynthetic process Source: UniProtKB
Positive regulation of intestinal cholesterol absorption Source: UniProtKB
Positive regulation of sphingomyelin catabolic process Source: UniProtKB
Regulation of intestinal lipid absorption Source: UniProtKB
Sphingomyelin catabolic process Source: InterPro
Sphingomyelin metabolic process Source: UniProtKB
Cellular Location
Cell membrane. The catalytic domain is released into the extracellular medium when cells are treated with trypsin (PubMed:15205117). Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex (PubMed:12671034, PubMed:12885774).
Topology
Extracellular: 22-433
Helical: 434-454
Cytoplasmic: 455-458
PTM
N-glycosylated; required for activity and transport to the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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