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Rabbit Anti-EPDR1 Recombinant Antibody (CBFYE-0955) (CBMAB-E1437-FY)

This product is rabbit antibody that recognizes EPDR1. The antibody CBFYE-0955 can be used for immunoassay techniques such as: ELISA.
See all EPDR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYE-0955
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human EPDR1 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ependymin Related 1
Introduction
The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
Entrez Gene ID
54749
UniProt ID
Q9UM22
Alternative Names
Ependymin Related 1; Upregulated In Colorectal Cancer Gene 1 Protein; MERP-1; MERP1; UCC1; Ependymin Related Protein 1 (Zebrafish)
Research Area
Binds anionic lipids and gangliosides at acidic pH.
Biological Process
Cell-matrix adhesion Source: InterPro
Myofibroblast contraction Source: UniProtKB
Cellular Location
Secreted; Lysosome lumen. Lysosomal and also secreted.
PTM
N-glycosylated; the glycan contains mannose-6-phosphate moieties.By similarity

Ahmed, T., Flores, P. C., Pan, C. C., Ortiz, H. R., Lee, Y. S., Langlais, P. R., ... & Lee, N. Y. (2022). EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex. Journal of Biological Chemistry, 298(9).

El-Masry, O. S., Alamri, A. M., Alzahrani, F., & Alsamman, K. (2022). ADAMTS14, ARHGAP22, and EPDR1 as potential novel targets in acute myeloid leukaemia. Heliyon, 8(3), e09065.

Yang, Y., Zhang, H., Liu, Z., Zhao, F., & Liang, G. (2021). EPDR1 is related to stages and metastasize in bladder cancer and can be used as a prognostic biomarker. BMC urology, 21(1), 1-12.

Liu, X., Liu, C., Zhang, A., Wang, Q., Ge, J., Li, Q., & Xiao, J. (2021). Long non-coding RNA SDCBP2-AS1 delays the progression of ovarian cancer via microRNA-100-5p-targeted EPDR1. World Journal of Surgical Oncology, 19(1), 1-9.

Zhao, Z., Wang, Z., Wang, P., Liu, S., Li, Y., & Yang, X. (2021). EPDR1, Which Is Negatively Regulated by miR-429, Suppresses Epithelial Ovarian Cancer Progression via PI3K/AKT Signaling Pathway. Frontiers in oncology, 11, 751567-751567.

Gimeno-Valiente, F., Riffo-Campos, Á. L., Ayala, G., Tarazona, N., Gambardella, V., Rodríguez, F. M., ... & Castillo, J. (2020). EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness. Scientific reports, 10(1), 1-14.

Chen, R., & Zhang, Y. (2020). EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker. Journal of cellular and molecular medicine, 24(20), 12107-12118.

Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., ... & Scheele, C. (2019). Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals EPDR1 as a novel batokine. Cell metabolism, 30(5), 963-975.

Wei, Y., Xiong, Z. J., Li, J., Zou, C., Cairo, C. W., Klassen, J. S., & Privé, G. G. (2019). Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. Communications biology, 2(1), 1-13.

Chu, C. H., Chang, S. C., Wang, H. H., Yang, S. H., Lai, K. C., & Lee, T. C. (2018). Prognostic values of EPDR1 hypermethylation and its inhibitory function on tumor invasion in colorectal cancer. Cancers, 10(10), 393.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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