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Mouse Anti-ERC1 Recombinant Antibody (CBFYE-1143) (CBMAB-E1703-FY)

This product is mouse antibody that recognizes ERC1. The antibody CBFYE-1143 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ERC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1143
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELKS/RAB6-Interacting/CAST Family Member 1
Introduction
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
23085
UniProt ID
Q8IUD2
Alternative Names
ELKS/RAB6-Interacting/CAST Family Member 1; RAB6 Interacting Protein 2; RAB6IP2; ERC-1; ELKS; Rab6-Interacting Protein 2; KIAA1081; Cast2
Research Area
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
Biological Process
I-kappaB phosphorylation Source: UniProtKB
Maintenance of presynaptic active zone structure Source: GO_Central
Multicellular organism development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neuromuscular synaptic transmission Source: GO_Central
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of synaptic plasticity Source: GO_Central
Regulation of transcription, DNA-templated Source: UniProtKB
Retrograde transport, endosome to Golgi Source: ParkinsonsUK-UCL
Cellular Location
Golgi apparatus membrane; Centrosome; Presynaptic cell membrane; Cytoplasm; Membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity).
Involvement in disease
A chromosomal aberration involving ERC1/RAB6IP2 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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