Mouse Anti-ERCC1 Recombinant Antibody (CBFYE-1146) (V2LY-0825-LY649)

ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit

ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit; Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1 (Includes Overlapping Antisense Sequence); Excision Repair Cross-Complementation Group 1; DNA Excision Repair Protein ERCC-1; COFS4; RAD10; UV20;

Isoform 1:
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

Isoform 2:
Not functional in the nucleotide excision repair pathway.

Isoform 3:
Not functional in the nucleotide excision repair pathway.

Isoform 4:
Not functional in the nucleotide excision repair pathway.

Cell population proliferation Source: Ensembl
DNA recombination Source: MGI
DNA repair Source: MGI
Double-strand break repair via nonhomologous end joining Source: BHF-UCL
Embryonic organ development Source: Ensembl
Interstrand cross-link repair Source: Ensembl
Isotype switching Source: Ensembl
Male gonad development Source: Ensembl
Meiotic mismatch repair Source: GO_Central
Mitotic recombination Source: UniProtKB
Multicellular organism aging Source: Ensembl
Multicellular organism growth Source: Ensembl
Negative regulation of protection from non-homologous end joining at telomere Source: BHF-UCL
Negative regulation of telomere maintenance Source: UniProtKB
Nucleotide-excision repair Source: MGI
Nucleotide-excision repair, DNA incision, 3'-to lesion Source: UniProtKB
Nucleotide-excision repair, DNA incision, 5'-to lesion Source: UniProtKB
Oogenesis Source: Ensembl
Positive regulation of t-circle formation Source: BHF-UCL
Positive regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
Post-embryonic hemopoiesis Source: Ensembl
Pyrimidine dimer repair by nucleotide-excision repair Source: Ensembl
Replicative senescence Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to sucrose Source: Ensembl
Response to X-ray Source: Ensembl
Spermatogenesis Source: Ensembl
Syncytium formation Source: Ensembl
T-circle formation Source: BHF-UCL
Telomeric DNA-containing double minutes formation Source: BHF-UCL
UV-damage excision repair Source: GO_Central
UV protection Source: Ensembl

Isoform 1&3&4: Nucleus
Isoform 2: Nucleus; Cytoplasm

Cerebro-oculo-facio-skeletal syndrome 4 (COFS4):
A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome.

Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages (PubMed:25538220). Deubiquitinated by USP45 (PubMed:25538220).