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Mouse Anti-ERO1B Recombinant Antibody (M37-P5D11) (CBMAB-AP2148LY)


See all ERO1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
M37-P5D11
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Peptide – LAPSRGEDDG
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Endoplasmic Reticulum Oxidoreductase 1 Beta
Introduction
ERO1B (Endoplasmic Reticulum Oxidoreductase 1 Beta) is a Protein Coding gene. Among its related pathways are Peptide hormone metabolism and Protein processing in endoplasmic reticulum. An important paralog of this gene is ERO1A.
Entrez Gene ID
56605
UniProt ID
Q86YB8
Alternative Names
Endoplasmic Reticulum Oxidoreductase 1 Beta; Endoplasmic Reticulum Oxidoreductin-1-Like Protein B; Endoplasmic Reticulum Oxidoreductase Beta; Oxidoreductin-1-L-Beta; ERO1-L-Beta; ERO1LB; Endoplasmic Oxidoreductin-1-Like Protein B;
Research Area
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
Biological Process
Protein folding Source: UniProtKB
Protein folding in endoplasmic reticulum Source: FlyBase
Cellular Location
Endoplasmic reticulum membrane. The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
PTM
N-glycosylated.
The Cys-90/Cys-95 and Cys-393/Cys-396 disulfide bonds constitute the redox-active center. The Cys-90/Cys-95 disulfide bond accepts electron from P4HB and funnel them to the active site disulfide Cys-393/Cys-396. The Cys-81/Cys-390 disulfide bond may be critical for structural stability. Two long-range disulfide bonds participate in loose feedback regulation. The Cys-90/Cys-130 disulfide bond may be the predominant regulatory switch to modulate the catalytic activity, while the Cys-100/Cys-262 disulfide bond may play an auxiliary regulatory role.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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