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Mouse Anti-ESRRG Recombinant Antibody (H6812) (CBMAB-E1914-FY)

This product is mouse antibody that recognizes ESRRG. The antibody H6812 can be used for immunoassay techniques such as: WB, IHC, IP, ELISA.
See all ESRRG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
H6812
Antibody Isotype
IgG2a
Application
WB, IHC, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Estrogen Related Receptor Gamma
Introduction
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
Entrez Gene ID
2104
UniProt ID
P62508
Alternative Names
Estrogen Related Receptor Gamma; Nuclear Receptor Subfamily 3 Group B Member 3; Estrogen Receptor-Related Protein 3; ERR Gamma-2; NR3B3; ERR3
Research Area
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).

Induces the expression of PERM1 in the skeletal muscle.
Biological Process
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Retinoic acid receptor signaling pathway Source: InterPro
Cellular Location
Nucleus
PTM
Acetylated by PCAF/KAT2 (in vitro).
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.

Field, M. G., Kuznetsoff, J. N., Zhang, M. G., Dollar, J. J., Durante, M. A., Sayegh, Y., ... & Harbour, J. W. (2022). RB1 loss triggers dependence on ESRRG in retinoblastoma. Science advances, 8(33), eabm8466.

Zou, Z., Harris, L. K., Forbes, K., & Heazell, A. E. (2022). Placental expression of Estrogen related receptor gamma (ESRRG) is reduced in FGR pregnancies and is mediated by hypoxia. Biology of reproduction.

Liang, Y., Chen, Y., Tian, T., Zhu, S., & Song, K. (2022). Molecular mechanism of the ESRRG-PERM1-CKMT2 signal axis in ovariectomized female rats with OSAHS. Transplant Immunology, 74, 101631.

Zou, Z., Forbes, K., Harris, L. K., & Heazell, A. E. (2021). The potential role of the ESRRG pathway in placental dysfunction. Reproduction, 161(3), R45-R60.

Li, W., Gong, M., Park, Y. P., Elshikha, A. S., Choi, S. C., Brown, J., ... & Morel, L. (2021). Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism. JCI insight, 6(14).

Peng, Z., Guan, Q., Luo, J., Deng, W., Liu, J., Yan, R., & Wang, W. (2020). Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer. BMC cancer, 20(1), 1-12.

Müller, S., Perdikari, A., Dapito, D. H., Sun, W., Wollscheid, B., Balaz, M., & Wolfrum, C. (2020). ESRRG and PERM1 govern mitochondrial conversion in brite/beige adipocyte formation. Frontiers in endocrinology, 11, 387.

Anelli, G. M., Mandò, C., Letizia, T., Mazzocco, M. I., Novielli, C., Lisso, F., ... & Cetin, I. (2019). Placental ESRRG-CYP19A1 expressions and circulating 17-beta estradiol in IUGR pregnancies. Frontiers in pediatrics, 7, 154.

Shen, Z., Hu, Y., Zhou, C., Yuan, J., Xu, J., Hao, W., ... & Ye, D. (2019). ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma. Journal of Clinical Laboratory Analysis, 33(6), e22899.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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