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Rat Anti-ETV2 Recombinant Antibody (CBFYE-1352) (CBMAB-E1966-FY)

This product is rat antibody that recognizes ETV2. The antibody CBFYE-1352 can be used for immunoassay techniques such as: WB.
See all ETV2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYE-1352
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse ETV2
Specificity
Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ets Variant 2
Introduction
ETV2 (ETS Variant 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is FLI1.
Entrez Gene ID
14008
UniProt ID
P41163
Alternative Names
Etsrp71
Research Area
Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Biological Process
Blastocyst development Source: Ensembl
Blood vessel morphogenesis Source: Ensembl
BMP signaling pathway involved in mesodermal cell fate specification Source: Ensembl
Cell differentiation Source: GO_Central
Erythrocyte differentiation Source: Ensembl
Notch signaling pathway Source: Ensembl
Placenta development Source: Ensembl
Positive regulation of endothelial cell differentiation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of mesoderm development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Wnt signaling pathway Source: Ensembl
Cellular Location
Nucleus

Li, J., Du, H., Ji, X., Chen, Y., Li, Y., Heng, B. C., & Xu, J. (2022). ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways. Stem Cell Research & Therapy, 13(1), 1-14.

Shrestha, S., Lamattina, A., Pacheco-Rodriguez, G., Ng, J., Liu, X., Sonawane, A., ... & El-Chemaly, S. (2022). ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells. Life science alliance, 5(5).

Mamoor, S. (2021). ETV2 is a differentially expressed gene in human metastatic breast cancer, in the brain and in the lymph nodes.

Shrestha, S., Lamattina, A., Pacheco-Rodriguez, G., Ng, J., Liu, X., Sonawane, A., ... & El-Chemaly, S. (2021). ETV2 regulates PARP-1 binding protein to induce ER stress-mediated cell death in tuberin-deficient cells. bioRxiv.

Singh, B. N., Sierra-Pagan, J. E., Gong, W., Das, S., Theisen, J. W., Skie, E., ... & Garry, D. J. (2020). ETV2 (Ets variant transcription factor 2)-Rhoj cascade regulates endothelial progenitor cell migration during embryogenesis. Arteriosclerosis, thrombosis, and vascular biology, 40(12), 2875-2890.

Kim, J. Y., Lee, D. H., Kim, J. K., Choi, H. S., Dwivedi, B., Rupji, M., ... & Park, C. (2019). ETV2/ER71 regulates the generation of FLK1+ cells from mouse embryonic stem cells through miR-126-MAPK signaling. Stem cell research & therapy, 10(1), 1-9.

Lee, D. H., Kim, T. M., Kim, J. K., & Park, C. (2019). ETV2/ER71 transcription factor as a therapeutic vehicle for cardiovascular disease. Theranostics, 9(19), 5694.

Yan, G., Yan, R., Chen, C., Zhao, Y., Qin, W., Veldman, M. B., ... & Lin, S. (2019). Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells. Protein & cell, 10(3), 217-222.

Li, X., Moon, G., Shin, S., Zhang, B., & Janknecht, R. (2018). Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases. Molecular Medicine Reports, 17(4), 5518-5527.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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