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Mouse Anti-ETV5 (AA 119-223) Recombinant Antibody (CBFYE-1357) (CBMAB-E1974-FY)

This product is mouse antibody that recognizes ETV5. The antibody CBFYE-1357 can be used for immunoassay techniques such as: ICC.
See all ETV5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1357
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Immunogen
E.coli-derived recombinant human ETV5, Asn119-Ser223
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 119-223

Target

Full Name
ETS Variant 5
Introduction
ETV5L (ETS Variant 5 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ETV3.
Entrez Gene ID
2119
UniProt ID
P41161
Alternative Names
ETS Variant 5; Ets-Related Protein ERM; Ets-Related Molecule; ERM; Ets Variant Gene 5 (Ets-Related Molecule); ETS Translocation Variant 5
Research Area
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
Biological Process
Cell differentiation Source: GO_Central
Cellular response to oxidative stress Source: UniProtKB
Male germ-line stem cell asymmetric division Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Ofori, J. K., Karagiannopoulos, A., Nagao, M., Westholm, E., Ramadan, S., Wendt, A., ... & Eliasson, L. (2022). Human islet microRNA-200c is elevated in type 2 diabetes and targets the transcription factor ETV5 to reduce insulin secretion. Diabetes, 71(2), 275-284.

Pedrana, G., Larrañaga, C., Diaz, A., Viotti, H., Lombide, P., Cavestany, D., ... & Sloboda, D. M. (2021). Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat. Reproduction, Fertility and Development, 33(7), 484-496.

Peng, Y., Feng, H., Wang, C., Song, Z., Zhang, Y., Liu, K., ... & Zhao, R. (2021). The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progression. Cell Death & Disease, 12(5), 1-11.

Zhang, L., Fu, R., Liu, P., Wang, L., Liang, W., Zou, H., ... & Tao, L. (2021). Biological and prognostic value of ETV5 in high-grade serous ovarian cancer. Journal of ovarian research, 14(1), 1-9.

Zhang, F., Wang, S., & Zhu, J. (2020). ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite ETS/E-box motifs. Journal of Biological Chemistry, 295(29), 10062-10075.

Meng, D., Li, Z., Ma, X., Wu, L., Fu, L., & Qin, G. (2020). ETV5 overexpression contributes to tumor growth and progression of thyroid cancer through PIK3CA. Life sciences, 253, 117693.

Mus, L. M., Lambertz, I., Claeys, S., Kumps, C., Van Loocke, W., Van Neste, C., ... & Speleman, F. (2020). The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness. Scientific reports, 10(1), 1-13.

Cheng, X., Jin, Z., Ji, X., Shen, X., Feng, H., Morgenlander, W., ... & Zhao, R. (2019). ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet‐derived growth factor BB. International journal of cancer, 145(1), 179-191.

Bullock, M., Lim, G., Zhu, Y., Åberg, H., Kurdyukov, S., & Clifton-Bligh, R. (2019). ETS factor ETV5 activates the mutant telomerase reverse transcriptase promoter in thyroid cancer. Thyroid, 29(11), 1623-1633.

Puli, O. R., Danysh, B. P., McBeath, E., Sinha, D. K., Hoang, N. M., Powell, R. T., ... & Hofmann, M. C. (2018). The transcription factor ETV5 mediates BRAFV600E-induced proliferation and TWIST1 expression in papillary thyroid cancer cells. Neoplasia, 20(11), 1121-1134.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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