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Mouse Anti-EXOC7 Recombinant Antibody (1B7) (CBMAB-A2750-LY)

The product is antibody recognizes EXOC7. The antibody 1B7 immunoassay techniques such as: WB, ELISA.
See all EXOC7 antibodies
Published Data
Fig.1 The cells expressing Exo70 was detected by Western blot.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EXOC7 (NP_001013861, 586 a.a. ~ 684 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
exocyst complex component 7
Introduction
EXOC7 is a component of the exocyst, which is an evolutionarily conserved octameric protein complex essential for exocytosis. The exocyst targets secretory vesicles at specific domains of the plasma membrane for cell surface expansion and protein secretion (Zuo et al., 2006 [PubMed 17086175]).[supplied by OMIM
Entrez Gene ID
23265
UniProt ID
Q9UPT5
Alternative Names
2-5-3p; DKFZp686J04253; EX070; EXO70; EXOC1; Exo70p; FLJ40965; FLJ46415; YJL085W
Research Area
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

It is required for neuron survival and plays an essential role in cortical development (By similarity).
Biological Process
Exocytosis Source: GO_Central
Protein transport Source: UniProtKB-KW
Regulation of entry of bacterium into host cell Source: AgBase
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Cellular Location
Cytosol; Cell membrane; Midbody ring. Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).
Involvement in disease
Neurodevelopmental disorder with seizures and brain atrophy (NEDSEBA):
An autosomal recessive disorder characterized by brain atrophy, seizures, and developmental delay. Disease severity is variable. Severely affected individuals develop symptoms in utero, which may lead to spontaneous abortion. Patients at the mildest end of the phenotypic spectrum have onset of seizures later in childhood and show developmental delay with mildly impaired intellectual development and minimal brain atrophy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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