Mouse Anti-EXOC7 Recombinant Antibody (CBFYE-0283) (V2LY-0825-LY940)

Name: Mouse Anti-EXOC7 Recombinant Antibody (CBFYE-0283)
SKU: V2LY-0825-LY940
Rating: 5 (1 reviews)

See all EXOC7 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0283

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 600-616 within an internal region of human Exo70.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

exocyst complex component 7

Entrez Gene ID

23265

UniProt ID

Q9UPT5

Research Area

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

It is required for neuron survival and plays an essential role in cortical development (By similarity).

Biological Process

Exocytosis Source: GO_Central
Protein transport Source: UniProtKB-KW
Regulation of entry of bacterium into host cell Source: AgBase
Regulation of macroautophagy Source: ParkinsonsUK-UCL

Cellular Location

Cytosol; Cell membrane; Midbody ring. Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).

Involvement in disease

Neurodevelopmental disorder with seizures and brain atrophy (NEDSEBA):
An autosomal recessive disorder characterized by brain atrophy, seizures, and developmental delay. Disease severity is variable. Severely affected individuals develop symptoms in utero, which may lead to spontaneous abortion. Patients at the mildest end of the phenotypic spectrum have onset of seizures later in childhood and show developmental delay with mildly impaired intellectual development and minimal brain atrophy.

Chen, Z. S., Huang, X., Talbot, K., & Chan, H. Y. E. (2021). A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Cell death & disease, 12(2), 1-19.

Guo, Y., Wang, X., Wang, K., & He, Y. (2020). Appraising the Value of Serum and Serum-Derived Exosomal LncRNA-EXOC7 as a Promising Biomarker in Cervical Cancer. Clinical Laboratory, 66(7).

Coulter, M. E., Musaev, D., DeGennaro, E. M., Zhang, X., Henke, K., James, K. N., ... & Walsh, C. A. (2020). Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Genetics in Medicine, 22(6), 1040-1050.

Wang, S., Crisman, L., Miller, J., Datta, I., Gulbranson, D. R., Tian, Y., ... & Shen, J. (2019). Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. Journal of Biological Chemistry, 294(52), 19988-19996.

Ramalho, D. M. G. (2018). Alternative Splicing of EXOC7 in Colorectal Cancer Development (Doctoral dissertation).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-EXOC7 Recombinant Antibody (CBFYE-0283)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-EXOC7 Recombinant Antibody (1D4) (CAT#: V2LY-0825-LY942)

Mouse Anti-EXOC7 Recombinant Antibody (E2006) (CAT#: V2LY-0825-LY939)

Mouse Anti-EXOC7 Recombinant Antibody (A2750) (CAT#: V2LY-0825-LY941)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry