Sign in or Register   Sign in or Register
  |  

Mouse Anti-EXOSC2 (AA 71-161) Recombinant Antibody (CBFYE-0285) (CBMAB-E0565-FY)

This product is mouse antibody that recognizes EXOSC2. The antibody CBFYE-0285 can be used for immunoassay techniques such as: ELISA.
See all EXOSC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0285
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 71-161

Target

Full Name
Exosome Component 2
Introduction
EXOSC2 (Exosome Component 2) is a Protein Coding gene. Diseases associated with EXOSC2 include Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies and Retinitis Pigmentosa. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity.
Entrez Gene ID
23404
UniProt ID
Q13868
Alternative Names
Exosome Component 2; Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4), 3 5 Exoribonuclease (RRP4); Ribosomal RNA-Processing Protein 4; RRP4; Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4), 3-5-Exoribonuclease; Exosome Complex Exonuclease RRP4
Research Area
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
Biological Process
CUT catabolic process Source: GO_Central
Exonucleolytic catabolism of deadenylated mRNA Source: GO_Central
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Nuclear polyadenylation-dependent rRNA catabolic process Source: GO_Central
Nuclear polyadenylation-dependent tRNA catabolic process Source: GO_Central
Nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription Source: GO_Central
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: GO_Central
Polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
Positive regulation of cell growth Source: UniProtKB
rRNA processing Source: ProtInc
U4 snRNA 3'-end processing Source: GO_Central
Cellular Location
Nucleolus; Nucleus; Cytoplasm
Involvement in disease
Short stature, hearing loss, retinitis pigmentosa, and distinctive facies (SHRF):
An autosomal recessive disorder characterized by childhood myopia, early onset retinitis pigmentosa, progressive sensorineural hearing loss, hypothyroidism, short stature, brachydactyly, recognisable facial gestalt, premature ageing and mild intellectual disability.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EXOSC2 (AA 71-161) Recombinant Antibody (CBFYE-0285)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare