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Rabbit Anti-FAM111B Recombinant Antibody (EG1160) (CBMAB-EN1390-LY)

The product is antibody recognizes F111B. The antibody EG1160 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:5000.
See all FAM111B antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1160
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human F111B.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Family With Sequence Similarity 111 Member B
Entrez Gene ID
374393
UniProt ID
Q6SJ93
Research Area
Serine protease.
Biological Process
DNA replication Source: GO_Central
Cellular Location
Nucleus; Chromatin
Involvement in disease
Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP):
An autosomal dominant form of hereditary poikiloderma, a genodermatosis characterized by mottled pigmentation, telangiectasia, and epidermal atrophy. POIKTMP features include tendon contracture, myopathy, and progressive pulmonary fibrosis. It manifests from early childhood with telangiectasia and pigmentary anomalies especially on the face and sun-exposed areas, tendon contractures that particularly involve the ankles and feet causing gait disturbance, and development of pulmonary fibrosis during the second decade of life resulting in progressive dyspnea and restrictive impairment of lung function.

Macchiaiolo, M., Panfili, F. M., Vecchio, D., Cortellessa, F., Gonfiantini, M. V., Buonuomo, P. S., ... & Bartuli, A. (2022). Expanding phenotype of FAM111B‐related disease focusing on liver involvement: Literature review, report of a case with end‐stage liver disease and proposal for a new acronym. American Journal of Medical Genetics Part A.

Arowolo, A., Rhoda, C., & Khumalo, N. (2022). Mutations within the putative protease domain of the human FAM111B gene may predict disease severity and poor prognosis: A review of POIKTMP cases. Experimental Dermatology, 31(5), 648-654.

Li, W., Hu, S., Han, Z., & Jiang, X. (2022). YY1-induced transcriptional activation of FAM111B contributes to the malignancy of breast cancer. Clinical Breast Cancer, 22(4), e417-e425.

Dokic, Y., Albahrani, Y., Phung, T., Patel, K., de Guzman, M., Hertel, P., & Hunt, R. (2020). Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis: Hepatic disease in a child with a novel pathogenic variant of FAM111B. JAAD case reports, 6(12), 1217-1220.

Kawasaki, K., Nojima, S., Hijiki, S., Tahara, S., Ohshima, K., Matsui, T., ... & Morii, E. (2020). FAM111B enhances proliferation of KRAS‐driven lung adenocarcinoma by degrading p16. Cancer science, 111(7), 2635-2646.

Zhang, Z., Zhang, J., Chen, F., Zheng, L., Li, H., Liu, M., ... & Yao, Z. (2019). Family of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis caused by a novel FAM 111B mutation. The Journal of Dermatology, 46(11), 1014-1018.

Sun, H., Liu, K., Huang, J., Sun, Q., Shao, C., Luo, J., ... & Ren, B. (2019). FAM111B, a direct target of p53, promotes the malignant process of lung adenocarcinoma. OncoTargets and therapy, 12, 2829.

Chen, F., Zheng, L., Li, Y., Li, H., Yao, Z., & Li, M. (2019). Mutation in FAM111B causes hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis. Acta dermato-venereologica, 99(7), 695-696.

Mercier, S., Küry, S., Nahon, S., Salort-Campana, E., Barbarot, S., & Bézieau, S. (2019). FAM111B mutation is associated with pancreatic cancer predisposition. Pancreas, 48(5), e41-e42.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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