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Rabbit Anti-F13B Recombinant Antibody (CBFYC-2628) (CBMAB-C2702-FY)

This product is rabbit antibody that recognizes F13B. The antibody CBFYC-2628 can be used for immunoassay techniques such as: ELISA.
See all F13B antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-2628
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human Coagulation Factor XIII B chainF13B Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
COAGULATION FACTOR XIII B CHAIN
Introduction
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Entrez Gene ID
2165
UniProt ID
P05160
Alternative Names
Coagulation Factor XIII B Chain; Protein-Glutamine Gamma-Glutamyltransferase B Chain; Coagulation Factor XIII, B Polypeptide; Fibrin-Stabilizing Factor B Subunit; Transglutaminase B Chain; FXIIIB; TGase
Research Area
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
Biological Process
Blood coagulation Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Factor XIII subunit B deficiency (FA13BD):
An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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