Mouse Anti-FAM175A Recombinant Antibody (CBXF-0272) (V2LY-0825-LY1316)

Name: Mouse Anti-FAM175A Recombinant Antibody (CBXF-0272)
SKU: V2LY-0825-LY1316
Rating: 5 (1 reviews)

See all FAM175A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0272

Application

WB, FC, IP

Immunogen

Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Family with sequence similarity 175 member A

Entrez Gene ID

84142

UniProt ID

Q6UWZ7

Research Area

Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Biological Process

Attachment of spindle microtubules to kinetochore Source: GO_Central
Chromatin organization Source: UniProtKB-KW
Double-strand break repair Source: UniProtKB
Mitotic G2 DNA damage checkpoint signaling Source: UniProtKB
Mitotic spindle assembly Source: GO_Central
Positive regulation of DNA repair Source: UniProtKB
Protein K63-linked deubiquitination Source: GO_Central
Response to ionizing radiation Source: UniProtKB

Cellular Location

Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs).

Involvement in disease

Breast cancer (BC):
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

PTM

Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1 (PubMed:17643121, PubMed:17525340, PubMed:17643122). Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM; this promotes recruitment of BRCA1 to sites of DNA damage (PubMed:26778126).

Kastnerova, L., Belousova, I. E., Michal, M., Ptakova, N., Michal, M., & Kazakov, D. V. (2020). Kaposi sarcoma in association with an extracavitary primary effusion lymphoma showing unusual intravascular involvement: report of a case harboring a FAM175A germline mutation. The American Journal of Dermatopathology, 42(1), 55-60.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-FAM175A Recombinant Antibody (CBXF-0272)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-FAM175A Recombinant Antibody (F2184) (CAT#: V2LY-0825-LY1317)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry