Mouse Anti-FAT2 Recombinant Antibody (8C5) (CBMAB-F0063-CQ)

Name: Mouse Anti-FAT2 Recombinant Antibody (8C5)
SKU: CBMAB-F0063-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8C5

Application

FC, IF, IHC-P, CyTOF

Immunogen

Purified recombinant human FAT2 fusion protein

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FAT Atypical Cadherin 2

Introduction

This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.

Entrez Gene ID

2196

UniProt ID

Q9NYQ8

Alternative Names

FAT Atypical Cadherin 2; Multiple Epidermal Growth Factor-Like Domains Protein 1; Multiple EGF-Like Domains Protein 1; Cadherin-Related Family Member 9; Cadherin Family Member 8; HFAT2; CDHF8; MEGF1; Multiple Epidermal Growth Factor-Like Domains 1;

Research Area

Involved in the regulation of cell migration (PubMed:18534823).

May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).

Biological Process

Cell-cell adhesion Source: GO_Central
Cell-substrate adhesion Source: UniProtKB
Epithelial cell migration Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB

Cellular Location

Cell membrane; Trans-Golgi network; Cell junction. Localized at adhesion zippers (early state of adherens junctions) of keratinocytes.

Involvement in disease

Spinocerebellar ataxia 45 (SCA45):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA45 is a slowly progressive, autosomal dominant form with onset in adulthood.

Topology

Extracellular: 19-4048
Helical: 4049-4069
Cytoplasmic: 4070-4349

Zhou, L., Yang, Y., Liu, M., Gan, Y., Liu, R., Ren, M., ... & Zhou, Y. (2021). Identification of the RP11-21C4. 1/SVEP1 gene pair associated with FAT2 mutations as a potential biomarker in gastric cancer. Bioengineered, 12(1), 4361-4373.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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