Sign in or Register   Sign in or Register
  |  

Mouse Anti-FAT2 Recombinant Antibody (8C5) (CBMAB-F0063-CQ)

This product is a mouse antibody that recognizes FAT2. The antibody 8C5 can be used for immunoassay techniques such as: FC, IF, IHC-P, CyTOF.
See all FAT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8C5
Antibody Isotype
IgG1, κ
Application
FC, IF, IHC-P, CyTOF

Basic Information

Immunogen
Purified recombinant human FAT2 fusion protein
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FAT Atypical Cadherin 2
Introduction
This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.
Entrez Gene ID
2196
UniProt ID
Q9NYQ8
Alternative Names
FAT Atypical Cadherin 2; Multiple Epidermal Growth Factor-Like Domains Protein 1; Multiple EGF-Like Domains Protein 1; Cadherin-Related Family Member 9; Cadherin Family Member 8; HFAT2; CDHF8; MEGF1; Multiple Epidermal Growth Factor-Like Domains 1;
Research Area
Involved in the regulation of cell migration (PubMed:18534823).

May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).
Biological Process
Cell-cell adhesion Source: GO_Central
Cell-substrate adhesion Source: UniProtKB
Epithelial cell migration Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Cellular Location
Cell membrane; Trans-Golgi network; Cell junction. Localized at adhesion zippers (early state of adherens junctions) of keratinocytes.
Involvement in disease
Spinocerebellar ataxia 45 (SCA45):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA45 is a slowly progressive, autosomal dominant form with onset in adulthood.
Topology
Extracellular: 19-4048
Helical: 4049-4069
Cytoplasmic: 4070-4349
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FAT2 Recombinant Antibody (8C5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare