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Rabbit Anti-FBP1 Recombinant Antibody (D2T7F) (CBMAB-CP0687-LY)

The product is antibody recognizes FBP1. The antibody D2T7F immunoassay techniques such as: WB.
See all FBP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D2T7F
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val106 of human FBP1/FBPase 1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fructose-Bisphosphatase 1
Introduction
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human2203
Mouse14121
Rat24362
UniProt ID
HumanP09467
MouseQ9QXD6
RatP19112
Alternative Names
Fructose-Bisphosphatase 1; D-Fructose-1;6-Bisphosphate 1-Phosphohydrolase 1; Fructose-1;6-Bisphosphatase 1; Liver FBPase; EC 3.1.3.11; FBPase 1; FBP; Growth-Inhibiting Protein 17; EC 3.1.3;
Research Area
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Biological Process
Cellular response to drug Source: UniProtKB
Cellular response to magnesium ion Source: UniProtKB
Dephosphorylation Source: UniProtKB
Fructose 1,6-bisphosphate metabolic process Source: GO_Central
Fructose 6-phosphate metabolic process Source: UniProtKB
Fructose metabolic process Source: GO_Central
Gluconeogenesis Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of glycolytic process Source: UniProtKB
Negative regulation of Ras protein signal transduction Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: CAFA
Regulation of gluconeogenesis Source: UniProtKB
Sucrose biosynthetic process Source: GO_Central
Cellular Location
Cytosol; Extracellular exosome; Nucleus; Cytoplasm
Involvement in disease
Fructose-1,6-bisphosphatase deficiency (FBP1D):
An autosomal recessive metabolic disorder characterized by impaired gluconeogenesis, and episodes of hypoglycemia and metabolic acidosis that can be lethal in newborn infants or young children.

Xu, Y., Hino, C., Baylink, D. J., Xiao, J., Reeves, M. E., Zhong, J. F., ... & Cao, H. (2022). Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia. Biomarker research, 10(1), 1-5.

Zhang, F., Liu, B., Deng, Q., Sheng, D., Xu, J., He, X., ... & Liu, S. (2021). UCP1 regulates ALDH-positive breast cancer stem cells through releasing the suppression of Snail on FBP1. Cell Biology and Toxicology, 37(2), 277-291.

Yang, X., Zhao, L., Pei, J., Wang, Z., Zhang, J., & Wang, B. (2020). CELF6 modulates triple-negative breast cancer progression by regulating the stability of FBP1 mRNA. Breast cancer research and treatment, 183(1), 71-82.

Mizuno, H., Kagoya, Y., Chiba, A., Koya, J., Masamoto, Y., & Kurokawa, M. (2019). Activated pentose phosphate pathway mediated by FBP1 upregulation supports progression of acute myeloid leukemia with high EVI1 expression. Cancer Research, 79(13_Supplement), 2611-2611.

Yang, L. N., Ning, Z. Y., Wang, L., Yan, X., & Meng, Z. Q. (2019). HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma. American journal of cancer research, 9(8), 1607.

Zhang, Y. P., Liu, K. L., Yang, Z., Lu, B. S., Qi, J. C., Han, Z. W., ... & Xin, H. (2019). The involvement of FBP1 in prostate cancer cell epithelial mesenchymal transition, invasion and metastasis by regulating the MAPK signaling pathway. Cell Cycle, 18(19), 2432-2446.

Kanai, S., Shimada, T., Narita, T., & Okabayashi, K. (2019). Phosphofructokinase-1 and fructose bisphosphatase-1 in canine liver and kidney. Journal of Veterinary Medical Science, 19-0361.

Sharma, A. G., Kanwal, S. K., Chhapola, V., & Kumar, V. (2018). Novel fructose bisphosphatase 1 gene mutation presenting as recurrent episodes of vomiting in an Indian child. Journal of Postgraduate Medicine, 64(3), 180.

Yun-jian, Z. H. A. N. G., Tong, L. U., & Yi, W. A. N. G. (2018). Status epilepticus due to fructose-1, 6-bisphosphatase deficiency caused by FBP1 gene mutation: case report and review of literature. Chinese Journal of Evidence-Based Pediatrics, 13(3), 219.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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