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Mouse Anti-FBXO11 Recombinant Antibody (V2-619820) (CBMAB-A2879-LY)

The product is antibody recognizes FBXO11. The antibody 1A2 immunoassay techniques such as: WB, ELISA.
See all FBXO11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-619820
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FBXO11 (NP_079409, 744 a.a. ~ 843 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
F-box protein 11
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
80204
UniProt ID
Q86XK2
Alternative Names
FBX11; FLJ12673; MGC44383; PRMT9; UBR6; UG063H01; VIT1
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Biological Process
Cellular protein modification process Source: HGNC-UCL
Protein ubiquitination Source: GO_Central
Regulation of apoptotic process Source: GO_Central
Sensory perception of sound Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central
Cellular Location
Nucleus; Chromosome
Involvement in disease
Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (IDDFBA):
An autosomal dominant developmental disorder with variable manifestations and onset in infancy or first years of life. Clinical features include intellectual disability, speech delay, hyperkinetic disorder, hyperactivity, seizures, pre- and postnatal growth retardation, microcephaly, and facial dysmorphism.

Chan, K. L., Gomez, J., Cardinez, C., Kumari, N., Sparbier, C. E., Lam, E. Y., ... & Dawson, M. A. (2022). Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses. Cancer Cell, 40(10), 1190-1206.

Qiao, D., Hu, C., Li, Q., & Fan, J. (2021). Circ-RBMS1 knockdown alleviates CSE-induced apoptosis, inflammation and oxidative stress via up-regulating FBXO11 through miR-197-3p in 16HBE cells. International Journal of Chronic Obstructive Pulmonary Disease, 16, 2105.

Xu, P., Scott, D. C., Xu, B., Yao, Y., Feng, R., Cheng, L., ... & Weiss, M. J. (2021). FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis. Blood, 137(2), 155-167.

Mei, J., Zhang, Y., Lu, S., & Wang, J. (2020). Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. Biomedicine & Pharmacotherapy, 129, 110326.

Schieber, M., Marinaccio, C., Bolanos, L. C., Haffey, W. D., Greis, K. D., Starczynowski, D. T., & Crispino, J. D. (2020). FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome. Blood cancer journal, 10(10), 1-12.

Shao, L., Zhang, X., & Yao, Q. (2020). The F‐box protein FBXO11 restrains hepatocellular carcinoma stemness via promotion of ubiquitin‐mediated degradation of Snail. FEBS Open bio, 10(9), 1810-1820.

Ba, Z., Zhou, Y., Yang, Z., Xu, J., & Zhang, X. (2019). miR-324-5p upregulation potentiates resistance to cisplatin by targeting FBXO11 signalling in non-small cell lung cancer cells. The Journal of Biochemistry, 166(6), 517-527.

Jansen, S., van der Werf, I. M., Innes, A. M., Afenjar, A., Agrawal, P. B., Anderson, I. J., ... & de Vries, B. (2019). De novo variants in FBXO11 cause a syndromic form of intellectual disability with behavioral problems and dysmorphisms. European Journal of Human Genetics, 27(5), 738-746.

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For research use only. Not intended for any clinical use.

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