Mouse Anti-FBXO41 Recombinant Antibody (6B6) (CBMAB-A2891-LY)

The product is antibody recognizes FBXO41. The antibody 6B6 immunoassay techniques such as: WB, ELISA.
See all FBXO41 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

6B6

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

FBXO41 (XP_377742.2, 400 a.a. ~ 498 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

F-box protein 41

Introduction

Members of the F-box protein family, such as FBXO41, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM

Entrez Gene ID

150726

UniProt ID

Q8TF61

Alternative Names

FLJ37709; Fbx41

Research Area

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Cellular Location

Cytosol

References

Quadros, A. R., Arazola, R. D., Álvarez, A. R., Pires, J., Meredith, R. M., Saarloos, I., ... & Toonen, R. F. (2022). Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation. Iscience, 25(4), 104069.

Agrawal, Y., Sharma, T., Islam, S., Nadkarni, K. S., & Santra, M. K. (2022). F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2. The International Journal of Biochemistry & Cell Biology, 106228.

Agrawal, Y., Nadkarni, K. S., Gupta, N. A., Manne, R. K., & Santra, M. K. (2022). F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells. Toxicology and Applied Pharmacology, 441, 115973.

Agra de Almeida Quadros, A. R. (2021). The Role of FBXO41 in Neuronal Function and Hippocampal Development.

King, C. R., AA Quadros, A. R., Chazeau, A., Saarloos, I., van der Graaf, A. J., Verhage, M., & Toonen, R. F. (2019). Fbxo41 promotes disassembly of neuronal primary cilia. Scientific reports, 9(1), 1-15.

King, C. R. (2018). Dissecting the role of Fbxo41 in neuronal development and signaling.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-FBXO41 (AA 400-498) Recombinant Antibody (CBXF-2903)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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