Mouse Anti-FBXW11 Recombinant Antibody (CBXF-2912) (CBMAB-F3619-CQ)

Name: Mouse Anti-FBXW11 Recombinant Antibody (CBXF-2912)
SKU: CBMAB-F3619-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2912

Application

ELISA, IF

Immunogen

Full length recombinant corresponding to aa1-530 from FBXW11 (AAH26213) with GST tag

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

F-box and WD repeat domain containing 11

Introduction

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Entrez Gene ID

23291

UniProt ID

Q9UKB1

Alternative Names

F-Box And WD Repeat Domain Containing 11; F-Box And WD Repeats Protein Beta-TrCP2; F-Box/WD Repeat-Containing Protein 1B; F-Box And WD-40 Domain Protein 1B; F-Box And WD-40 Domain Protein 11; Homologous To Slimb Protein; FBXW1B; BTRCP2; FBW1B;

Research Area

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564).

Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).

(Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Biological Process

Brain morphogenesis Source: GO_Central
Establishment of mitotic spindle orientation Source: GO_Central
Germ cell development Source: GO_Central
Microtubule organizing center organization Source: GO_Central
Negative regulation of transcription, DNA-templated Source: UniProtKB
Nuclear migration Source: GO_Central
Positive regulation of circadian rhythm Source: UniProtKB
Positive regulation of proteolysis Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein dephosphorylation Source: UniProtKB
Protein destabilization Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of microtubule motor activity Source: GO_Central
Retrograde axonal transport Source: GO_Central
Rhythmic process Source: UniProtKB-KW
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Vesicle transport along microtubule Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Neurodevelopmental, jaw, eye, and digital syndrome (NEDJED):
An autosomal dominant syndrome characterized by variable features including mild-to-severe developmental delay, speech delay, autistic and/or stereotypical behaviors, ocular anomalies, under- or overdeveloped jaw, and digital anomalies such as brachydactyly, clinodactyly, syndactyly, and contractures.

Wang, L., Piao, Y., Zhang, D., Feng, W., Wang, C., Cui, X., ... & Zheng, G. (2022). Fbxw11 impairs the repopulation capacity of hematopoietic stem/progenitor cells. Stem cell research & therapy, 13(1), 1-14.

Chen, C., Zhou, H., Zhang, X., Liu, Z., & Ma, X. (2022). Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma. Cancer Biomarkers, (Preprint), 1-9.

Zhang, Q., Yin, X., & Zhang, Y. (2021). MicroRNA-221 promotes cell proliferation and inhibits apoptosis in osteosarcoma cells by directly targeting FBXW11 and regulating Wnt signaling. Archives of Medical Research, 52(2), 191-199.

Yao, J., Yang, J., Yang, Z., Wang, X. P., Yang, T., Ji, B., & Zhang, Z. Y. (2021). FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer. Cell death & disease, 12(10), 1-11.

Sun, J., Qin, X., Zhang, X., Wang, Q., Zhang, W., & Wang, M. (2021). FBXW11 deletion alleviates Alzheimer’s disease by reducing neuroinflammation and amyloid-β plaque formation via repression of ASK1 signaling. Biochemical and Biophysical Research Communications, 548, 104-111.

Zhang, Q., Zheng, J., & Liu, L. (2019). The long noncoding RNA PCGEM1 promotes cell proliferation, migration and invasion via targeting the miR-182/FBXW11 axis in cervical cancer. Cancer Cell International, 19(1), 1-15.

Holt, R. J., Young, R. M., Crespo, B., Ceroni, F., Curry, C. J., Bellacchio, E., ... & Ragge, N. K. (2019). De novo missense variants in FBXW11 cause diverse developmental phenotypes including brain, eye, and digit anomalies. The American Journal of Human Genetics, 105(3), 640-657.

Chang, H., Liu, Y. H., Wang, L. L., Wang, J., Zhao, Z. H., Qu, J. F., & Wang, S. F. (2018). MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer. American journal of translational research, 10(4), 1131.

Wang, L., Feng, W., Yang, X., Yang, F., Wang, R., Ren, Q., ... & Zheng, G. (2018). Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-κB and β-catenin/TCF signaling pathways. Cell death & disease, 9(4), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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