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Mouse Anti-FBXW8 Recombinant Antibody (CBXF-1732) (CBMAB-F3267-CQ)

This product is a mouse antibody that recognizes FBXW8. The antibody CBXF-1732 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FBXW8 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBXF-1732
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-Box And WD Repeat Domain Containing 8
Introduction
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Entrez Gene ID
Mouse231672
Rat304522
UniProt ID
MouseQ8BIA4
RatP0DL28
Alternative Names
F-Box And WD Repeat Domain Containing 8; F-Box Only Protein 29; F-Box And WD-40 Domain-Containing Protein 8; F-Box And WD-40 Domain Protein 8; FBXO29; FBXW6;
Research Area
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988).

Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745).

The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026).

Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).
Biological Process
Cell population proliferation Source: UniProtKB
Golgi organization Source: UniProtKB
Labyrinthine layer blood vessel development Source: Ensembl
Positive regulation of dendrite morphogenesis Source: UniProtKB
Positive regulation of transcription factor catabolic process Source: Ensembl
Protein ubiquitination Source: UniProtKB
Spongiotrophoblast layer development Source: Ensembl
Cellular Location
Golgi apparatus; Perinuclear region. Colocalizes with CUL7 at the Golgi apparatus in neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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